Titlebook: G-Quadruplex Nucleic Acids; Methods and Protocol Danzhou Yang,Clement Lin Book 2019 Springer Science+Business Media, LLC, part of Springer

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1064-3745 and experienced researchers who work in biophysics, structural biology, computational biology, biochemistry, and molecular and cell biology, and who want to learn more about the potential roles and effects of G-quadruplex in these fields.?. ..978-1-4939-9668-1978-1-4939-9666-7Series ISSN 1064-3745 Series E-ISSN 1940-6029

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,Newton and Leibniz – Giants and Opponents,-rich DNA and RNA sequences, G-quadruplexes can readily form under physiologically relevant conditions and are globularly folded structures. DNA is widely recognized as a double-helical structure essential in genetic information storage. However, only ~3% of the human genome is expressed in protein;

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A. Huth-Kühne,P. Lages,R. Zimmermannonal properties of nucleic acids. The reason is its high sensitivity to even slight changes in mutual orientation of absorbing bases of DNA. CD can reveal formation of particular structural DNA arrangements and can be used to search for the conditions stabilizing the structures, to follow the transi

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Gabi Ben-Dor,Oren Sadot,Ozer Igraptimization of potent G-quadruplex ligands for use in therapeutics, diagnostics, or other technological applications. Isothermal titration calorimetry (ITC) can resolve energetic contributions to complex formation and constitutes the only available experimental method to directly measure binding ent

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A.E. Lutsky,I.V. Mursenkova,I.A. Znamenskayareal time, without the need for labeling any components of the interaction. The method provides real-time equilibrium and kinetic characterization for quadruplex DNA interactions and requires small amounts of materials and no external probe. A detailed protocol for quadruplex-DNA interaction analyse

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R. Zhou,B. L. Tian,X. P. Li,J. P. Wangcterized thermodynamically, providing the information on the stability of various G4 conformations. We show how the relevant thermodynamic and sometimes kinetic parameters are obtained by employing differential scanning calorimetry (DSC) and global fitting of an appropriate model to the DSC data. We