| 書目名稱 | G-Quadruplex DNA | | 副標(biāo)題 | Methods and Protocol | | 編輯 | Peter Baumann | | 視頻video | http://file.papertrans.cn/381/380019/380019.mp4 | | 概述 | Includes coverage of a wide range of methodologies to study G-quadruplex structures.Provides detailed protocols which ensure successful re-recreation of experimental procedures.Supplies step-by-step i | | 叢書名稱 | Methods in Molecular Biology | | 圖書封面 |  | | 描述 | .Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In "G-Quadruplex DNA: Methods and Protocols", experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular Biology? series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls...Authoritative and cutting-edge, "G-Quadruplex DNA: Methods and Protocols "promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of | | 出版日期 | Book 2010 | | 關(guān)鍵詞 | DNA; Drug development; G-quartet formation and dynamics; Guanine bases; Molecular recognition; Oligonucle | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-59745-363-9 | | isbn_softcover | 978-1-4939-5639-5 | | isbn_ebook | 978-1-59745-363-9Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2010 |
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