Titlebook: G-Protein-Coupled Receptor Dimers; Katharine Herrick-Davis,Graeme Milligan,Giuseppe D Book 2017 Springer International Publishing AG 2017

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Class C GPCR: Obligatory Heterodimerization of GABAB Receptortively open. Receptor activation requires the formation of a novel heterodimer interface between membrane proximal domains. In this chapter we review the discovery of GABA. receptor, the critical role of heterodimerization to receptor function, the conformational state of the heterodimer at rest, an

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1048-6909 enting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.978-3-319-86795-3978-3-319-60174-8Series ISSN 1048-6909 Series E-ISSN 2524-6488

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S. Heinz,S. Friedman,E. Churazovand most members of the class B GPCR family can not only form homo-dimers, but also associate with each other to form hetero-complexes. Such complexes can explain agonist-induced cross-internalization of the associated receptors, providing an important mechanism for receptor regulation. It will be i

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