Titlebook: G Proteins, Receptors, and Disease; Allen M. Spiegel (Chief, Metabolic Diseases Branch Book 1998 Springer Science+Business Media New York

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Introduction to G-Protein-Coupled Signal Transduction and Human Disease,er reviews our current understanding of the structure and function of G proteins and the receptors to which they couple, offers some general considerations on how mutations in G proteins and GPCR cause disease, and gives a broad overview of disorders caused by defects in G-protein-coupled signal tra

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,Gα12- and Gα13-Subunits of Heterotrimeric G-Proteins A Novel Family of Oncogenes,t a common structural motif consisting of the presence of seven transmembrane-spanning domains ., a property that was also predicted for the protein product of the . oncogene on the basis of its nucleotide sequence .. This finding provided the first link between cellular transformation and GPCRs.

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Hypo- and Hyperthyroidism Caused by Mutations of the TSH Receptor,vailability of iodine. Regulation of thyroid function is thus mainly of a “tonic” nature, with virtually no physiological circumstances in which the gland should be put completely at rest. This chapter concentrates on the regulatory actions of thyrotropin via its receptor.

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Book 1998 basis of diseases ranging from obesity to malignancy. The basic understanding of the complex signal transduction process achieved here provides a firm foundation for future efforts to prevent and cure these diseases.

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Allen M. Spiegel (Chief, Metabolic Diseases Branch