Titlebook: G Protein-Coupled Receptors in Drug Discovery; Wayne R. Leifert Book 2009 Humana Press 2009 Calcium.Cellular signalling.Chemokine.Drug dev

格言

舉止粗野的人

創(chuàng)作

New Insights into GPCR Function: Implications for HTS,ique targeted therapeutic uses, including “designer” drugs such as allosteric regulators, inverse agonists, and drugs targeting hetero-oligomeric complexes. This has been facilitated by the development of new screening technologies to identify novel drugs against both known and orphan GPCRs.

滔滔不絕地說

An Overview on GPCRs and Drug Discovery: Structure-Based Drug Design and Structural Biology on GPCRf structure-based drug design has been possible. Much effort has been dedicated to structural biology on GPCRs and very recently an X-ray structure of the β2-adrenergic receptor was obtained. This breakthrough will certainly increase the efforts in structural biology on GPCRs and furthermore speed up and facilitate the drug discovery process.

Prognosis

cipher

航海太平洋

BacMam: Versatile Gene Delivery Technology for GPCR Assays,ample, coexpression of a receptor and a G protein or a reporter gene. BacMam viruses are compatible with the GPCR cell-based assay formats typically used in high-throughput screening and provide an unparalleled level of experimental flexibility that is simply not possible when using stable recombinant cell lines.

新陳代謝

籠子

Resonant Waveguide Grating Biosensor for Whole-Cell GPCR Assays,disease relevant environments. We have shown that these biosensor assays enable high-throughput screening of pathway-biased ligands acting on endogenous β.-adrenergic receptor in cells. These biosensor cellular assays hold the potential to reduce attrition rates in drug discovery and development process.

泰然自若