Titlebook: G Protein-Coupled Receptors; Immobilization and A Xinfeng Zhao,Qian Li,Jia Quan Book 2023 The Author(s), under exclusive license to Springe

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180 Keywords Geld- und W?hrungsrechtpound libraries and natural product extracts are the widely used two sources for bioactive compound screening. In this chapter, we aim to review some representative immobilized GPCR-based methods for the discovery of the bioactive compounds targeting the receptors, which may provide insight into the high throughput screening of lead compounds.

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G Protein-Coupled Receptors, is of?paramount importance for drug discovery. This chapter summarizes the structures, conformations, and signaling pathways of different GPCRs, providing an overview of GPCRs for drug discovery purposes.

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978-981-99-0077-0The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023

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G Protein-Coupled Receptors978-981-99-0078-7Series ISSN 2191-5407 Series E-ISSN 2191-5415

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2191-5407 ons.Reviews the applications of protein immobilizationThis book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the “post-structural bio

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The Informal Logic of Mathematical Proof,les. In this chapter, we summarize several key biochemical parameters, such as binding affinity and kinetics, dynamic conformational ensembles of drug targets, drug resistance time, rebinding, binding thermodynamics, and ligand efficiency.

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https://doi.org/10.1007/978-3-642-72830-3abilization of GPCR using different detergents and styrene-maleic acid–lipid particles. We also highlight the commonly used purification techniques for GPCRs?in literature. Finally, the heterologous expression systems for GPCRs, ranging from bacteria and yeasts to insects, mammalian cells, and ., and the successful purification cases are reviewed.