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G Protein-Linked Opioid Receptors,nal and nonneuronal cells. In 1973, researchers in three different laboratories demonstrated the presence of receptors specific for opiates in preparations from brain and intestine (.; .; .). These studies satisfied the criteria first enunciated by . for a narcotic receptor that is specific for the

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G Protein-Coupled melatonin receptors,d other systems in mammals. This indoleamine hormone is also involved in maintaining brain homeostasis, entraining biological rhythms and coordinating reproductive function to changes in photoperiod, particularly in seasonal breeders (.; .; .). Other studies indicate a potentially important immunomo

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G Proteins and Mood Disorders,eurotransmitter systems in mood disorder have been very suggestive, although not conclusive, of alterations in these systems (noradrenergic, dopaminergic, serotonergic, and cholinergic) possibly owing to changes in receptor sensitivity (Post and Ballenger, 1984). These data have resulted in a recent

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G Proteins in the Medial Temporal Lobe in Schizophrenia,antitative evidence of brain pathology in the form of enlarged third and lateral ventricles and increased cortical markings suggestive of reduced gyral mass or atrophy (Johnstone et al., 1976; Shelton and Weinberger, 1986; Suddath et al., 1989). In addition, controlled studies of postmortem brain ti

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,G Proteins and Animal Models of Parkinson’s Disease,persensitivity can be brought about in a number of ways, most commonly by receptor antagonist treatment or through denervation (.). In both cases, the dopamine receptor system has received a great deal of attention and is generally accepted as the prototype for the study of receptor supersensitivity

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Molecular Mechanisms of Opiate Addiction in the Nucleus Accumbens,siological state that necessitates the continued administration of the abused drug to prevent the appearance of a withdrawal syndrome. Withdrawal is characterized by psychological and perhaps physical disturbances when the abused drug is withdrawn. The goal of this chapter is to review the evidence