| 書(shū)目名稱(chēng) | Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane | | 編輯 | Ksenia Guseva | | 視頻video | http://file.papertrans.cn/347/346025/346025.mp4 | | 概述 | Nominated as an outstanding contribution by the University of Aberdeen.Contains essential new results on the statistical mechanics and dynamics of macromolecular assembly.Yields important conclusions | | 叢書(shū)名稱(chēng) | Springer Theses | | 圖書(shū)封面 |  | | 描述 | .With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transp | | 出版日期 | Book 2012 | | 關(guān)鍵詞 | Macromolecular dynamics; Mechanosensitive channels; Membrane functional organization; Outstanding PhD t | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-23988-5 | | isbn_softcover | 978-3-642-26994-3 | | isbn_ebook | 978-3-642-23988-5Series ISSN 2190-5053 Series E-ISSN 2190-5061 | | issn_series | 2190-5053 | | copyright | Springer-Verlag Berlin Heidelberg 2012 |
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