| 書目名稱 | Fluorescent Tools for Imaging Oxidative Stress in Biology |
| 編輯 | Amandeep Kaur |
| 視頻video | http://file.papertrans.cn/345/344737/344737.mp4 |
| 概述 | Nominated as an outstanding Ph.D. thesis by the University of Sydney, Australia.Outlines new reversible fluorescent redox sensors to visualise subcellular oxidative stress.Demonstrates successful appl |
| 叢書名稱 | Springer Theses |
| 圖書封面 |  |
| 描述 | .This thesis advances the long-standing challenge of measuring oxidative stress and deciphering its underlying mechanisms, and also outlines the advantages and limitations of existing design strategies. It presents a range of approaches for the chemical synthesis of fluorescent probes that detect reversible changes in cellular oxidative stress. The ability to visualise cellular processes in real-time is crucial to understanding disease development and streamline treatment, and this can be achieved using fluorescent tools that can sense reversible disturbances in cellular environments during pathogenesis. The perturbations in cellular redox state are of particular current interest in medical research, since oxidative stress is implicated in the pathogenesis of a number of diseases..The book investigates different strategies used to achieve ratiometric fluorescence output of the reversible redox probes, which nullify concentration effects associated with intensity-based probes. It also describes suitable approaches to target these probes to specific cellular organelles, thereby enabling medical researchers to visualise sub-cellular oxidative stress levels, and addressing the typicall |
| 出版日期 | Book 2018 |
| 關鍵詞 | Ratiometric Fluorescent Probes; Oxidative Stress; Flavin-based Redox Probes; Nicotinamide-based Redox P |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-73405-7 |
| isbn_softcover | 978-3-030-10371-2 |
| isbn_ebook | 978-3-319-73405-7Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer International Publishing AG 2018 |
|Archiver|手機版|小黑屋|
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