| 書目名稱 | Filaggrin | | 副標(biāo)題 | Basic Science, Epide | | 編輯 | Jacob P. Thyssen,Howard I. Maibach | | 視頻video | http://file.papertrans.cn/343/342757/342757.mp4 | | 概述 | First book to be devoted to the subject.Comprehensive overview of the effects of FLG mutations in health and disease.Wide appeal to the many different specialties that work with this area | | 圖書封面 |  | | 描述 | Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. | | 出版日期 | Book 2014 | | 關(guān)鍵詞 | Clinical disease; Disease patterns; Ichthyosis vulgaris; Treatment | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-54379-1 | | isbn_softcover | 978-3-662-51117-6 | | isbn_ebook | 978-3-642-54379-1 | | copyright | Springer-Verlag Berlin Heidelberg 2014 |
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