| 書目名稱 | Fibrosis in Disease | | 副標題 | An Organ-Based Guide | | 編輯 | Monte S. Willis,Cecelia C. Yates,Jonathan C. Schis | | 視頻video | http://file.papertrans.cn/343/342532/342532.mp4 | | 概述 | Written by established experts in their fields..Provide new insight into the fundamental mechanisms of classic fibrotic pathophysiologic processes..Highlights the many new areas of therapeutic investi | | 叢書名稱 | Molecular and Translational Medicine | | 圖書封面 |  | | 描述 | .Fibroproliferative diseases are a broad spectrum of entities from organ-specific involvement (e.g., pulmonary, heart, liver, and kidney fibrosis) to multi-system diseases such as systemic sclerosis and sclerodermatous graft vs. host disease. These diseases also encompass pathophysiologies not readily recognizably related, such as macular degeneration and cancer metastasis. Fibroproliferative diseases are a leading cause of morbidity and mortality and can affect all tissues and organ systems. Remarkable progress in elucidating the pathogenesis of these common diseases with fibrotic components, including the critical roles of myofibroblasts and the molecular mechanisms driving the transcriptional activation involved in the induction of fibrosis. As the importance of these processes is realized in the long-term recovery and treatment of diseases, effective anti-fibrotic therapies targeting the underlying ongoing disease processes are lacking...The complexity of discovering and applying therapies to fibroproliferative disease may be due to the diversity of the systems the pathogenesis of disease itself involves. By nature, fibroproliferative diseases are interdisciplinary, involving m | | 出版日期 | Book 2019 | | 關鍵詞 | Chemokines; systemic sclerosis; Fibrotic Signaling; peptidomics; hepatic fibrosis; Anti-Fibrotic Therapie | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-98143-7 | | isbn_ebook | 978-3-319-98143-7Series ISSN 2197-7852 Series E-ISSN 2197-7860 | | issn_series | 2197-7852 | | copyright | Springer Nature Switzerland AG 2019 |
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