| 書(shū)目名稱 | Fabry Disease | | 編輯 | Deborah Elstein,Gheona Altarescu,Michael Beck | | 視頻video | http://file.papertrans.cn/341/340190/340190.mp4 | | 概述 | first full-length textbook about Fabry disease.includes chapters on the therapeutic management options.complete and stat-of-the-art range of pre-clinical studies.comprehensive chapters on clinical fin | | 圖書(shū)封面 |  | | 描述 | Fabry disease is an X-linked inborn error of metabolism wherein deficiency of a lysosomal enzyme results in systemic deposition of glycosphingolipids. Storage deposition, and hence pathological disease, occurs preferentially in renal glomerular and tubular epithelial cells, myocardial cells, heart valve fibrocytes, neurons of dorsal root ganglia, and in endothelial smooth muscle cells of blood vessels. Thus, Fabry disease is a multi-system disorder, albeit with considerable phenotypic heterogeneity in onset and in severity; however, it is progressive, exhibits extensive morbidity, and is life-threatening. Within the past two decades, there has been a radical change in the natural course Fabry disease by virtue of the availability of specific enzyme replacement therapy. Moreover, there has been a concerted effort to better understand the underlying pathology and equally to identify patients prior to the onset of irreversible end-organ damage. It is to be hoped that the future for patients with Fabry disease can be viewed with greater, albeit guarded, optimism. This state-of-the-art textbook attempts to bridge the span of pre-clinical studies, clinical finding, and management options | | 出版日期 | Book 2010 | | 關(guān)鍵詞 | blood vessel; bone; cells; endothelium; genetics; smooth muscle; metabolic disease | | 版次 | 1 | | doi | https://doi.org/10.1007/978-90-481-9033-1 | | isbn_softcover | 978-94-007-9884-7 | | isbn_ebook | 978-90-481-9033-1 | | copyright | Springer Science+Business Media B.V. 2010 |
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