Titlebook

發(fā)源

L-Asparaginase in the Treatment of Neoplastic Diseases of the Dog, Cat and Cow] and are predominantly of lymphatic or hematopoeitic origin. Rarely, other tumor types, including a rat fibrosarcoma [8], a mouse mammary carcinoma [15], and two cases of human malignant melanoma [6, 12] may be suppressed by treatment with asparaginase.

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Influence of L-Asparaginase Preparations of E. coli and Agouti Serum on the Homograft Reactivity in in mice treated with high doses of the enzymepreparation. . described inhibition of the graft-versus-host reaction in mice and rats receiving E. coli L-asparaginase [8]. Suppression of phytohemagglutinin-induced transformation of human lymphocytes was reported by . et al. [1] and by . [12].

制度

Studies on the Immunosuppressive Activity of L-Asparaginasece of resistance in mice bearing a leukemia which is sensitive to the drug (. and ., 1969) (personal unpublished findings); secondly, L-asparaginase shows immunosuppressive activities in a number of tests.

Anthropoid

Studies on the Control of Asparagine Biosynthesis in Mammalian Tissuesparagine (ASN) [7, 9, 14]. With other malignant or normal tissues the relationship is not clear. From the early studies of the . effects of ASNase by . [10] and the . nutritional requirements for ASN by . et al. [11] and others [3, 15], it became apparent that under certain injection regimes or cult

expeditious

Some Physicochemical Aspects of L-Asparaginase Therapyin the circulation of the host, is apparently a function of the source of the preparation [5]. In early attempts to detect the difference between two such samples (one from Bayer and one from Squibb), each was subjected to gel filtration on a G-200 Sephadex column. Identical activity patterns were o

Nomadic

Fecal-Impaction

單色

The Partitioning of L-Asparaginase between Blood and Lymphnase must penetrate into the micro-environment of the tumor cells if it is have significant effect. Since, even in leukemias, it is likely that many of the tumor cells are in the extravascular compartment and since asparaginase is usually administered intravenously it follows that the ability of the

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