Titlebook: Extrasynaptic GABAA Receptors; Adam C. Errington,Giuseppe Di Giovanni,Vincenzo Cr Book 2014 Springer Science+Business Media, LLC 2014 GABA

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978-1-4939-5321-9Springer Science+Business Media, LLC 2014

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https://doi.org/10.1007/978-3-658-25544-2smitter receptors, the ionotropic receptors, known as GABA. receptors, and metabotropic receptors that are classified as GABA. receptors. The classical phasic inhibitory postsynaptic potential (IPSP) is mediated by GABA. receptors that are located in the postsynaptic membrane. However, GABA also pro

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Grundlegendes zum Inklusionsbegriffthose containing the subunits α4, α5, α6, and δ are preferentially located outside of the postsynaptic density and are activated tonically by GABA. Owing to their subunit composition, these extrasynaptic GABA.R have specific functional properties and pharmacological profiles that distinguish them fr

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https://doi.org/10.1007/978-3-658-26602-8 the generation of a tonic conductance that has been shown to influence neuronal excitability (see other chapters). In the current chapter, we explore the many factors that can influence the ambient GABA concentration paying particular attention to how GABA synthesis, release, diffusion and uptake b