Titlebook: Exploring Protein Structure: Principles and Practice; Tim Skern Textbook 2018 Springer International Publishing AG, part of Springer Natur

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Exploring the Peptide Bond,les in the main chain and how to decide whether a proline residue is in the . or . configuration. Finally, two internet algorithms are introduced that allow you to generate a Ramachandran plot from any protein structure in the PDB.

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The Rationale Behind This Workbook, because I sensed a need to support my students to move forward from the theoretical knowledge of protein structure obtained in their biochemistry courses to a more active interaction that would enable them to make use of the huge amount of information on macromolecular structures stored in the Prot

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Exploring the Peptide Bond,e properties of the peptide bond. Using the modest but biochemically famous protein RNase A, you will discover how to measure the bond lengths and angles in the main chain and how to decide whether a proline residue is in the . or . configuration. Finally, two internet algorithms are introduced that

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Exploring Protein-Ligand and Protein-Protein Interactions,t protein is p21., a molecule that binds guanosine diphosphate (GDP) in the ground state and guanosine triphosphate (GTP) in the activated state. It is of therapeutic interest because activation can be brought about by the hormone insulin; in addition, p21. is often mutated in human cancers. The sec

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,Examining α-Helical Proteins,erically and that their chemical properties are compatible. The packing of α-helices of closely related proteins can be very similar; however, slight variations and the presence of different amino acids can lead to different properties and functions. First, we will investigate the structure of three

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,Investigating Proteins with β-Sheets,in the structures of proteins composed mostly of β-sheets. One common arrangement of β-strands is called a β-sandwich because two sets of hydrogen-bonded strands pack back to back; the side-chains are the filling of the sandwich. As a classic example, we will examine the immunoglobulin fold and its

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978-3-319-76857-1Springer International Publishing AG, part of Springer Nature 2018