Titlebook: Explorations in Aging; Vincent J. Cristofalo,Jay Roberts,Richard C. Adelm Book 1975 The Editor(s) (if applicable) and The Author(s), under

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Neoplasms of the Salivary Glandsates in bacteria, therefore, the proportion of diploid cells which survive mutagen treatment should be at least 10. times that of haploid cells. A haploid-diploid comparison should, in fact, be a test for the mutagenic nature of a compound.

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https://doi.org/10.1007/978-1-4615-9032-3aging; biology; cell; perception; regulation; relationships; research; senescence

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978-1-4615-9034-7The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines

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0065-2598 o the biology of aging and our perceptions of the sub- ject matter. However, three years ago we began to hold informal meetings to discuss our research. These meetings eventually be- came more frequent and, with this association, we became increas- ingly cognizant of the commonality of our research

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Regulation of Cell Division in Aging Mouse Mammary Epithelium, is that of continuous cell culture, in which normal diploid tissue cells, even though provided with every known requirement and stimulus, for growth, nevertheless display an inevitable decline in proliferative capacity, followed by senescent changes and eventual loss of the culture.

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The Development of the Bony Skull,tional to chronological age between two and at least 24 months (1–3). Many other enzyme adaptations in a variety of tissues from several different species also are altered in time course and/or magnitude of response during aging (4).

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