Titlebook: Experimental Neurotoxicology Methods; Jordi Llorens,Marta Barenys Book 2021 Springer Science+Business Media, LLC, part of Springer Nature

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The Functional Observation Battery: Utility in Safety Assessment of New Molecular EntitiesThe rat functional observational battery is the regulatory standard assay for the assessment of the central nervous system prior to the first dose administration in man. This chapter describes the utility and scientific foundation for the general adoption of this technique by both European and the United States drug regulatory agencies.

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Book 2021ver a variety of available methods from the molecular level to the organism level, and both in vitro and in vivo approaches, including alternative model organisms. In the .Neuromethods. series style, chapters include the kind of detail and key advice from the specialists needed to get successful res

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Jean-Paul Bravard,Pauline Gaydoubefore confocal microscopy imaging. The data thus obtained offer a thorough evaluation of the damage suffered by the vestibular sensory epithelia, including overt hair cell loss and subtle synaptic loss. Together, these pathological outcomes determine the loss vestibular input and the resulting behavioral alterations.

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Evaluation of Cellular and Molecular Pathology in the Rodent Vestibular Sensory Epithelia by Immunofbefore confocal microscopy imaging. The data thus obtained offer a thorough evaluation of the damage suffered by the vestibular sensory epithelia, including overt hair cell loss and subtle synaptic loss. Together, these pathological outcomes determine the loss vestibular input and the resulting behavioral alterations.

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