Titlebook: Experimental Models of Parkinson’s Disease; Yuzuru Imai Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license

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α-Synuclein Seeding Assay Using RT-QuICrted that αSyn RT-QuIC exhibits specificity between 82% and 100%, while its sensitivity varies between 70% and 100%, on the basis of a study in which this assay was performed at multiple different laboratories. Furthermore, it has been suggested that the αSyn RT-QuIC method can be applied to study t

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1064-3745 own pitfalls.?.Authoritative and practical, .Experimental Models of Parkinson‘s Disease. is an ideal guide for researchers continuing to work toward making PD risk predictable and surmountable..978-1-0716-1497-6978-1-0716-1495-2Series ISSN 1064-3745 Series E-ISSN 1940-6029

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α-Synuclein Seeding Assay Using RT-QuIC’s disease, dementia with Lewy bodies, and multiple system atrophy. In each disease, it has been proposed that aggregates of αSyn represent different conformational strains of αSyn, leading to self-propagation and spreading from cell to cell. It has been considered that αSyn aggregates grow by seede

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Electron Microscopic Analysis of α-Synuclein Fibrils disease, dementia with Lewy bodies, and multiple system atrophy (MSA). The synaptic protein α-syn is water-soluble under normal physiological conditions, but in these patients’ brains, we see accumulation of insoluble amyloid-like α-syn fibrils with prion-like properties. Intracerebral accumulation

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