Titlebook: Experimental Models of Parkinson’s Disease; Yuzuru Imai Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license

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Grundlegende Begriffe und S?tze disease, dementia with Lewy bodies, and multiple system atrophy (MSA). The synaptic protein α-syn is water-soluble under normal physiological conditions, but in these patients’ brains, we see accumulation of insoluble amyloid-like α-syn fibrils with prion-like properties. Intracerebral accumulation

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Geometry -Intuition and Conceptsase lead to the accumulation of glucosylceramide, which causes the development of the lysosomal storage disease known as Gaucher’s disease. Loss-of-function mutations in the . gene are the most important genetic risk factor for synucleinopathies, such as Parkinson’s disease and dementia with Lewy bo

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Surfaces of Negative Curvature,mal regulation. We have previously shown that endogenous LRRK2 recruited its substrates Rab8a and Rab10 onto overloaded lysosomes depending on their phosphorylation, which functioned in the suppression of lysosomal enlargement as well as the promotion of the exocytic release of lysosomal cathepsins.

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V. N. Berestovskij,I. G. Nikolaeviseases, considering the difficulty to obtain live pathological tissue. The midbrain dopaminergic neurons of the substantia nigra are mainly affected in Parkinson’s disease, but it is impossible to obtain and analyze viable dopaminergic neurons from live patients. This problem can be overcome by the

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Lattices, packings and tilings in the plane,INK1 and Parkin, regulate mitochondrial autophagy, called mitophagy, and motility. Dopaminergic neurons derived from human-induced pluripotent stem (iPS) cells are a useful tool for analyzing the pathogenesis caused by defects in mitochondrial quality control and for screening candidate drugs for PD

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