Titlebook: Experimental Models of Multiple Sclerosis; Ehud Lavi,Cris S. Constantinescu Book 2005 Springer-Verlag US 2005 Antigen.Chemokine.Nervous Sy

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Neuroantigens in EAEThis chapter reviews briefly the biology of myelin and describes the major CNS myelin proteins, the potential neuroantigens in EAE. The genetics of the principal myelin proteins are also discussed. Myelin glycolipids with potential role in CNS demyelinating disease and the enzymes involved in their synthesis are also reviewed.

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B Cells and Antibodies in Experimental Autoimmune EncephalomyelitisEAE is a T cell mediated disease, but increasing evidence shows an important role for B cells and antibodies in its pathogenesis. This also reflects a role for humoral factors in the pathogenesis of multiple sclerosis. The main functions of B cells and antibodies in EAE are discussed.

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Adjuvants in EAE cell-mediated immunity, including EAE. An additional adjuvant, pertussis toxin, is necessary for active EAE in mice. The mechanisms of action of adjuvants are multiple, but important actions are stimulation of proinflammatory cytokines and costimulatory molecules.

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The Role of Astrocytes in Autoimmune Disease of the Central Nervous Systemf astrocytes includes the formation and maintenance of the blood brain barrier (BBB), and the supply of structural support and nourishment to neurons. This article will discuss the role of astrocytes in multiple sclerosis (MS) and other inflammatory autoimmune diseases of the CNS. We will address th

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The Neuron and Axon in Experimental Autoimmune EncephalomyelitisEAE, these processes are being investigated in great detail. This chapters discusses the present knowledge of axonal and neuronal pathology in MS and details the relevant studies in EAE, that may form the basis to future neuroprotective/regenerative approaches to MS.

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Endothelial Cells and Adhesion Molecules in Experimental Autoimmune Encephalomyelitisctivation, cells of the immune system undergo changes that allow for an immune response within the CNS. The animal model, experimental autoimmune encephalomyelitis (EAE), is an important tool by which to investigate these processes. Using EAE, it has been shown that the establishment of an immune re