Titlebook: Evolutionary Systems Biology; Advances, Questions, Anton Crombach Book 2021Latest edition The Editor(s) (if applicable) and The Author(s),

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Externe Berater erfolgreich einsetzene grown under a specific selective pressure, mutations arise over time, and lineages carrying mutations that increase fitness can outcompete others. Here we discuss how experimental evolution has allowed us to study various evolutionary processes, from clonal interference to diminishing-returns epis

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Externe Faktoren im Demokratisierungsproze?of enzyme kinetics. In addition, metabolism is interlinked with gene regulation and other cellular, energy-driven processes such as division and motility. While many important insights have been gained on metabolism in the last decades, we are still far from a complete, predictive understanding of i

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https://doi.org/10.1007/978-3-663-08488-4the genotype-phenotype map. Gene regulatory circuits occupy a central position in this map, because they control when, where, and to what extent genes are expressed, and thus drive fundamental physiological, developmental, and behavioral processes in living organisms as different as bacteria and hum

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https://doi.org/10.1007/978-3-319-20382-9 ignores, or at least does not exploit, Dobzhansky’s wisdom. In this perspective paper, we argue and demonstrate the importance of using evolutionary methods to derive relevant parameters. We show that by doing so, we can debug experimental and modeling artifacts.

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Modeling Complex Biological Systems: Tackling the Parameter Curse Through Evolution, ignores, or at least does not exploit, Dobzhansky’s wisdom. In this perspective paper, we argue and demonstrate the importance of using evolutionary methods to derive relevant parameters. We show that by doing so, we can debug experimental and modeling artifacts.

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Determination of Nuclear Quadrupole Moments,concepts, tools and results. In particular, we will show how complex models can be used to explore this question and show that complexity can spontaneously accumulate even in simple conditions owing to a “complexity ratchet” fuelled by sign epistasis.