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Titlebook: Etiology: Chemical and Physical Carcinogenesis; Frederick F. Becker Book 1982 Springer Science+Business Media New York 1982

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發(fā)表于 2025-3-21 20:04:40 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Etiology: Chemical and Physical Carcinogenesis
編輯Frederick F. Becker
視頻videohttp://file.papertrans.cn/317/316394/316394.mp4
叢書名稱Cancer, a compresensive treatise
圖書封面Titlebook: Etiology: Chemical and Physical Carcinogenesis;  Frederick F. Becker Book 1982 Springer Science+Business Media New York 1982
描述Six years ago when the first edition of this volume appeared as the first of the series, questions were posed in its preface that are as valid today as they were then. In that preface, I proposed the following challenges: (1) We must identify carcinogenic agents, and by an analysis of their "nature," e. g. , structure and physical characteristics, we may better understand their mechanism of action. (2) We must identify crucial interactions between these carcinogens and impor- tant macromolecules within the cell, distinguishing those which relate to carcinogenesis from those which are extraneous. (3) We must examine the alterations of cell function induced by these reactions, for it is with an understanding of phenotypic variation that we may know why malignant cells escape from normal homeostatic control. (4) Last, and perhaps of greatest importance, we must define malignancy--define those charac- teristics of cellular activity that permit the malignant cell to compete so effectively with the normal constituent, which ultimately Ieads to such destructive events. Although great strides have been made toward those goals, as evidenced by a number of new chapters and the new informatio
出版日期Book 1982
版次1
doihttps://doi.org/10.1007/978-1-4615-6598-7
isbn_softcover978-1-4615-6600-7
isbn_ebook978-1-4615-6598-7
copyrightSpringer Science+Business Media New York 1982
The information of publication is updating

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https://doi.org/10.1007/978-3-319-54166-2tempt to approximate this model, we instead say this host will more often develop this disease if exposed to this agent than if not exposed. The agent or environment (i.e., many agents) may then be considered to be causally associated with this disease.
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https://doi.org/10.1057/9781137463661a variety of tissue nucleophiles including DNA, RNA, and protein, and (3)the development of model systems for a sequential analysis of the initiation phase of carcinogenesis. This chapter primarily focuses on the interactions of chemical carcinogens and their activated metabolites with nucleic acids, both DNA and RNA.
地板
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Piyush Tiwari,Jyoti Rao,Jennifer Daycience, medicine, and industry. In historical perspective, the effects of radiation have received greater study than those of any other physical agent of comparable environmental significance. As such, our experience with radiation is applicable to the study and control of other environmental carcinogens.
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Biophysical Aspects of Radiation Carcinogenesisrely the first purely physical process—that of energy deposition by charged particles—is highly com-plex and difficult to quantitate. There is every reason to believe that the ensuing physicochemical, biochemical, intracellular, intercellular, and systemic processes are at least as complex and that many of them are unknown at this time.
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Chemical Carcinogenesis: Interactions of Carcinogens with Nucleic Acidsa variety of tissue nucleophiles including DNA, RNA, and protein, and (3)the development of model systems for a sequential analysis of the initiation phase of carcinogenesis. This chapter primarily focuses on the interactions of chemical carcinogens and their activated metabolites with nucleic acids, both DNA and RNA.
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Physical Carcinogenesis: Radiation—History and Sourcescience, medicine, and industry. In historical perspective, the effects of radiation have received greater study than those of any other physical agent of comparable environmental significance. As such, our experience with radiation is applicable to the study and control of other environmental carcinogens.
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