Titlebook: Estrogens, Progestins, and Their Antagonists; Functions and Mechan Edward J. Pavlik Book 1997 Springer Science+Business Media New York 1997

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External Use of the South African Randn D. (VDR), retinoic acid (RAR), and a number of other nuclear receptors for which a ligand has not yet been identified. Members of the nuclear receptor family are modular proteins composed of separate domains for ligand binding, DNA binding, and transcriptional enhancement.

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Overview of Fixed Exchange Rate Regimes,e transcriptional level. Much recent work on steroid receptors has focused on receptor-DNA interaction, a late step in the steroid signal transduction pathways. On the other hand, mechanisms that regulate the early events, such as phosphorylation and dissociation, remain obscure (Orti et al, 1992).

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Dominant Negative Activity by Estrogen and Progesterone ReceptorsTRβ appears to be competition for DNA binding to TREs between mutant TR complexes (homo — and/or heterodimers) and ligandbound wild-type TR (Figure 1, panel B) (Nagaya et al, 1992; Yen et al, 1992). The exclusion of transcriptionally active TR complexes from binding to the TRE results in blockade of T.-stimulated transcriptional activation.

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