Titlebook: Estrogen Receptor and Breast Cancer; Celebrating the 60th Xiaoting Zhang Book 2019 Springer Nature Switzerland AG 2019 estrogen receptor.br

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,A Novel Strategy to Improve Women’s Health: Selective Estrogen Receptor Modulators, with a safe SERM but to prevent breast cancer at the same time. Raloxifene is the result with no increase in endometrial cancer incidence. There are now five FDA-approved SERMS available for use: tamoxifen, raloxifene, bazedoxifene, toremifene, and ospemifene. All have connections with discovery and basic research in Jordan’s laboratory.

Cytology

Emerging Therapeutic Approaches to Overcome Breast Cancer Endocrine Resistance, 1 (MED1) using small molecules, antibodies, and RNA nanotechnology. We will also provide future perspective for other potential novel therapeutic targets such as epigenetic modification, noncoding RNAs, immunotherapy, etc. and the expansion of therapeutic options in endocrine-resistant breast cancers.

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Estrogen Receptor and Breast Cancer: A Historical Perspective,estrogen and a few more decades when Elwood Jensen announced the discovery of estrogen receptor. His work led to our understanding of how hormones control target gene transcription via their receptors. Several laboratories made major contributions toward our understanding of hormone action. To date,

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Physiological and Pathological Roles of Estrogen Receptor,clear activities of two receptor protein isoforms, ERα and ERβ, and multiple cell signaling mechanisms, including non-genomic and genomic actions. Genomic actions involve either direct DNA binding or tethered gene regulation. We describe herein some of the physiological responses of estrogen occurri

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Estrogen Receptor-Mediated Gene Transcription and Cistrome,ype nuclear receptor that primarily functions as a transcription factor. In this chapter, we will first describe the conserved domain architecture of ER and its regulation through various modifications by diverse intracellular pathways. We will then discuss the history and most recent advancement in

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The Estrogen-Regulated Transcriptome: Rapid, Robust, Extensive, and Transient,r estrogens, the hormone acts by stimulating the DNA binding and transcriptional activity of estrogen receptors (ERs), transcription factors which robustly and transiently regulate the expression of target genes. More broadly, estrogen signaling controls the ER cistrome, as well as the epigenome and

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