Titlebook: Erythropoietins, Erythropoietic Factors, and Erythropoiesis; Molecular, Cellular, Steven G. Elliott,Mary Ann Foote,Graham Molineux Book 200

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Role and regulation of iron metabolism in erythropoiesis and diseasects on red blood cell production and function. This chapter provides an overview of the proteins and pathways involved in iron metabolism as they relate to normal red blood cell biology and disorders of iron excess or deficiency.

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2296-6056 ythropoietic factor. Once EPO was identified, cloned, and expressed, the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.978-3-7643-8698-6Series ISSN 2296-6056 Series E-ISSN 2296-6064

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Book 2009Latest editionO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified, cloned, and expressed, the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.

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Erythropoiesis: an overview mL/kg/min and body stores are approximately five times greater, emphasizing the need to maintain a stable red cell mass while having the capacity to increase red cells during times of tissue hypoxia [.,.]. Changes in the production of erythrocytes from a steady-level will occur in response to blood

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Regulation of endogenous erythropoietin productione tissues was confirmed by showing that there was more oxygen in arterial than venous blood [.]. Finally, a specific role for erythrocytes in oxygen transport was established by the demonstration of reversible binding of oxygen to the pigmented haemoglobin that accounted for the colour change [., .]

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Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietinthe endogenous hormone by stimulating the production of red blood cells. Patients with chronic kidney disease are unable to produce adequate amounts of endogenous erythropoietin (EPO) to stimulate red blood cell production. Patients with cancer often have damaged bone marrow, with or without the ins

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Commercial production of recombinant erythropoietinsing glycosylation forms with the desired efficacy in humans, are typically selected as hosts. The host mammalian cells secrete the rHuEPO product into the medium environment in which they are cultured, making the remainder of production a matter of separating the rHuEPO product from the cells and ot

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