Titlebook: Epstein-Barr Virus and Human Disease · 1990; D. V. Ablashi,A. T. Huang,Kristin? L. Ablashi Book 1991 Springer Science+Business Media New Y

休閑

We have previously shown by gel-shift assay.-d by BJAB Dells upon activation by TPA (., .). These anti-E1 proteins could inhibit, compete and uncouple the . fic binding of E iA-1 to the . .Under denaturing conditions by SDS-PAGE, the molecular weight of the anti-EBNA1 proteins were 40,000 and 60,000, respectively. Here, we stowed that non-dena

控訴

How Zebra, A Weak Transactivator, Exerts Strong Biologic Effectsuct which controls the transition between viral latency and lytic viral replication; therefore ZEBRA is worthy of the increasing efforts to understand in molecular detail the control of its expression and its mechanism of action.

招人嫉妒

EBNA-2 Transactivation of CD23-2 induces both viral and cellular gene expression including the EBV latent membrane protein (LMP1), CD21, CD23, and . (3,4,5,6,7). CD23 is a B lymphocyte activation marker which is closely associated with EBV induced B lymphocyte growth transformation (8,9). Recent studies of CD23 expression in BJA

Malleable

EBNA-2 Transactivation of LMP1pression of six viral nuclear proteins, two viral integral membrane proteins and two viral small RNAs (for review see 1). EBV nuclear protein 2 (EBNA-2) is one of the first genes expressed following primary B lymphocyte infection, in vitro (2, 3, 4, 5). EBNA-2 transactivates expression of LMP1 (6 ,7

閹割

A New Lymphoid-Specific Epstein-Barr Virus Enhancer is Transactivated by EBNA-2 biologically intertwined, with most of the identified EBV latent gene products being expressed in immortalized cells. Of the handful of EBV genes expressed during latency, we focus on two of the nuclear antigens, or EBNA’s.

障礙

RUPT

EBNA-2 Influences Promoter Function in Burkitt Lymphoma Cellsmutant P3HR-1, cannot express latent cycle proteins other than EBNA-4-LP in primary B lymphocytes (2). This suggested that a gene affected by the HR-1 deletion is required for the expression of other EBNAs in primary B lymphocytes. We are now studying the molecular mechanism underlying this observat

accomplishment

Functional Characterization of Epstein-Barr Virus DNA Polymerase by , ,Transcription-Translation of e is essential for viral replication, the study of this enzyme should provide information useful for the rational design of drugs for antiviral chemotherapy and a deeper understanding of the control mechanism of EBV replication.

Conduit

FUME