Titlebook: Epstein Barr Virus Volume 2; One Herpes Virus: Ma Christian Münz Book 2015 The Editor(s) (if applicable) and The Author(s), under exclusive

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EBNA2 and Its Coactivator EBNA-LPlatent EBV infection is the expression of several distinct and well-defined viral latent transcription programs called latency I, II, and III. Growth transformation of B-cells by EBV in vitro is based on the concerted action of Epstein-Barr virus nuclear antigens (EBNAs) and latent membrane proteins

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The EBNA3 Family: Two Oncoproteins and a Tumour Suppressor that Are Central to the Biology of EBV inproliferate by the virus. Together with the other nuclear antigens (EBNA-LP, EBNA2 and EBNA1), they are expressed from a polycistronic transcription unit that is probably unique to B cells. However, compared with the other EBNAs, hitherto the EBNA3 proteins were relatively neglected and their roles

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Latent Membrane Protein 2 (LMP2)quitin ligases and an ITAM that binds to SH2 domain-containing proteins, (b) a transmembrane domain with 12 transmembrane segments that localizes LMP2A in cellular membranes, and (c) a 27-amino acid C-terminal domain which mediates homodimerization and heterodimerization of LMP2 protein isoforms. Th

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EBV Noncoding RNAsionally regulate viral and/or cellular gene expression. With recent advances in RNA sequencing technologies, the list of identified EBV ncRNAs continues to grow. EBV-encoded RNAs (EBERs), the BamHI-A rightward transcripts (BARTs), a small nucleolar RNA (snoRNA), and viral microRNAs (miRNAs) are all

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Viral Entryntry into these two cell types in vitro have been identified, and their roles in attachment and fusion are being explored. This chapter discusses what is known about entry at the cellular level in vitro and describes what little is known about the process in vivo. It highlights some of the questions

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Epstein-Barr Virus-Specific Humoral Immune Responses in Health and Diseasedisease syndromes. Humoral immune responses to EBV have been studied for diagnostic, pathogenic and protective (vaccine) purposes. These studies use a range of methodologies, from cell-based immunofluorescence testing to antibody-diversity analysis using immunoblot and epitope analysis using recombi

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T-Cell Responses to EBVion. Despite this high frequency of carriage, the virus causes apparently few adverse effects in the vast majority of infected individuals. Nevertheless, the potent growth transforming ability of EBV means the virus has the potential to cause malignancies in infected individuals. Indeed, EBV is thou