Titlebook: Epigenomics; Anne C. Ferguson-Smith,John M. Greally,Robert A. M Book 2009 Springer Science+Business Media B.V. 2009 Chromosom.DNA.Epigenet

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Introduction: A Movable Armenia,cations are two types of epigenetic modifications that are highly correlated with regulation of gene expression, genome imprinting and gene silencing. Although epigenomic research has added to our understanding of biological phenomena, little work has been done to establish statistical methods that

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Knowledge-Based Expert Systems,s increased interest is driven by new technologies that have allowed us to gain insights never previously possible. Our view of cytosine methylation is expanding not only in terms of how much of the genome we can study at a time, but also in terms of what we think cytosine methylation might be doing

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An Artificial Wicksell—Keynes Macroeconomylity of core transcription machinery (Dvir et al. 2001, Sandelin 2007), the actions of promoter- or regulon-specific transcription factors (positive and negative) (e.g., (Malik and Roeder 2005, Hoffmann et al. 2006)), and the control of DNA accessibility by altering chromatin structure (Li et al. 20

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Spiritual Direction: Dancing with the Other, of replication. Replication-independent histone variants of H3 and H2A have evolved to participate in gene regulation, transcriptional elongation, chromosome segregation and DNA repair in almost all eukaryotes. Because histone variants are deposited on a chromatinized template, they replace canonic

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International Space Law and Norms,paramutation and imprinting. Current efforts are beginning to yield an understanding of the molecular mechanisms responsible for these epigenetic behaviors. Complementary research in many organisms has now provided strong evidence for the role of repetitive DNA features in facilitating epigenetic co

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Legacies of the San Sebastian Mine,zation and cohesion, proper centromere function, and silencing. Schizosaccharomyces pombe is a useful model organism for the study of initiation, maintenance, and inheritance of epigenetic marks. Recent publications in the field have helped to explain the mechanism and functional consequences of pro

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