Titlebook: Epigenetics of Aging; Trygve O. Tollefsbol Book 2010 Springer-Verlag New York 2010 Chromosom.DNA.Telomere.aging.genetics.senescence

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Telomeres, Epigenetics, and Aging telomere function. How both aspects are connected and how they impact on organismal fitness will be the subject of intense research in the coming years. This chapter reviews different aspects of telomere biology and discusses their implications in the aging process.

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Contributions of Tumor Suppressors to the Epigenetic Regulation of Aging Cells. Covalent modifications of histones and DNA methylation are the most common epigenetic modifications that influence the activity of various growth stimulatory and inhibitory genes. Cellular senescence might be viewed as a state when the “balance” of gene activity is skewed in the favour of growth i

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Book 2010sses, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an imp

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Vertriebsbedingte Erfolgsursachen,compacting DNA. The balance between the activity of HATs and HDACs regulates transcription, but with aging this balance is lost, leading to either gene overactivity (e.g., in cancer cells) or gene repression that can lead to neurodegeneration during the aging process.

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