Titlebook: Epigenetic Therapy of Cancer; Preclinical Models a Michael Lübbert,Peter A. Jones Book 2014 Springer-Verlag Berlin Heidelberg 2014 Carcinom

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Clinical Implications of Epigenetic Alterations in Lung Cancer,

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Epigenetic Therapies in Solid Tumours: From Preclinical Models to Clinical Trial Results,

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th present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.978-3-662-51928-8978-3-642-38404-2

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Michael Lübbert,Peter A. JonesDevotes detailed attention to the translation of basic research and drug development to clinical applications in the treatment of solid tumors as well as hematologic malignancies and hemoglobinopathy.

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978-3-662-51928-8Springer-Verlag Berlin Heidelberg 2014

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Book 2014roaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epi