Titlebook: Epigenetic Regulation of Lymphocyte Development; Cornelis Murre Book 2012 The Editor(s) (if applicable) and The Author(s), under exclusive

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https://doi.org/10.1007/978-3-642-24103-1CD4 co-receptor; CD8 co-receptor; IgH locus recombination; T helper cell lineages; T-cell identity; recom

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Wie “Alternativ” ist “Unbezahlte” Arbeit?llular identity and function. While most cells in a complex metazoan organism express hundreds of such transcription factors, the underlying mechanisms by which they ultimately achieve their functional locations within different cell types remain poorly understood. Here, we contrast various models o

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https://doi.org/10.1007/978-3-322-83467-6 the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its target genes via a DNA-binding domain including a unique ‘zinc knuckle’, which mediates a novel mode of DNA recognition. Chromatin immun

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The epiCS? Skin Irritation Test (SIT) Methodession that is maintained while access to alternative hematopoietic lineages is permanently renounced. This combination of features could be explained by environmentally responsive transcription factor mobilization overlaying an epigenetically stabilized base gene expression state. For example, “poi

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https://doi.org/10.1007/978-981-16-4698-0e expression of the CD4 co-receptor on helper cells and the CD8 co-receptor on cytotoxic cells is intimately linked to this decision, and their regulation at the transcriptional level has been the subject of intense study to better understand lineage choice. Indeed, as the fate of developing T cells

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