Titlebook: Enzymology and Molecular Biology of Carbonyl Metabolism 7; Henry Weiner,Edmund Maser,Ronald Lindahl Book 1999 The Editor(s) (if applicable

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Aldehyde Dehydrogenase Catalytic Mechanismted that the crystal structure of a class 3 ALDH (E-NAD binary complex) revealed a non-traditional mode of NAD-binding within an open β/α domain otherwise familiar in the NAD-binding “ossmann folds” of other dehydrogenases (Liu et al., 1997a). The variability of residues in the substrate-binding sit

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Inhibition of Human Mitochondrial Aldehyde Dehydrogenase by Metabolites of Disulfiram and Structuralase (ALDH2), a key ene by virtue of its low K. for acetaldehyde (Mascher & Kikuta, 1992; Greenfield & Pietruszko, 1977). Disulfiram is rapidly reduced . to .-diethyldithiocarbamate (DDC) (Cobby .., 1977) which is further metabolized as shown in Scheme 1. The general consensus is that disulfiram is t

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Mechanism of Inhibition of Rat Liver Class 2 ALDH by 4-Hydroxynonenal cytotoxic, aldehydic products (Esterbauer ., 1991). 4-hydroxy-2-.-nonenal (4-HNE) malondialdehyde (MDA), the most abundant aldehydes produced during lipid peroxidation, have a relatively long half-life and are capable of diffusing to distant sites within the cell of origin or into adjacent cells. 4

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A Thioester Analogue of an Amino Acetylenic Aldehyde Is A Suicide Inhibitor of Aldehyde Dehydrogenastanoic acid (B), an intermediate in the methionine salvage pathway is a potent inducer of apoptosis when added to cultures of mouse lymphoid cells BAF. bo (Quash et al., 1995). MTOB a00 μM was also capable of alleviating the methionine dependence shown by transfed cells (Ogier et al., 1993) because

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Reaction between Sheep Liver Mitochondrial Aldehyde Dehydrogenase and A Chromogenic ‘Reporter Group’ and giving an inactive from the enzyme in which Cys-302 carries a -CO-NMe. label (Kitson et al., 1991) is work led to the idea that a cyclic analogue of the carbamate would constitute a ‘eporter group’ reagent of the type originally envisaged by Burr and Koshland (1964), since the chromophoric .-ni

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