Titlebook: Enzymology and Molecular Biology of Carbonyl Metabolism 7; Henry Weiner,Edmund Maser,Ronald Lindahl Book 1999 The Editor(s) (if applicable

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Enzymology and Molecular Biology of Carbonyl Metabolism 7978-1-4615-4735-8Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Sapna Tyagi,Deepak Rajpurohit,Amit Sharma arrive at the consensus of invariable residues that are essential for catalysis; a conserved feature during evolution. Thus, 16 different aldehyde dehydrogenases were compared by Hempel et al., (1993)who found 23 invariable amino acid residues by alignment of sequences available at that time.

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Reaction-Chemistry-Directed Sequence Alignment of Aldehyde Dehydrogenases arrive at the consensus of invariable residues that are essential for catalysis; a conserved feature during evolution. Thus, 16 different aldehyde dehydrogenases were compared by Hempel et al., (1993)who found 23 invariable amino acid residues by alignment of sequences available at that time.

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Effect of Arachidonic Acid Alone or with Prooxidant on Aldehyde Dehydrogenases in Hepatoma Cellsenous toxic aldehydes (Linda 1992; Yoshida, 1992) and against endogenous aldehydes, such as those derived from ld peroxidation (Lindahl and Petersen, 1991; Canuto et al., 1994). The latter appear to influence cell growth and differentiation in some tumour cell lines (Barrera et al., 1994; Canuto et al., 1995).

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The Externalization of Agricultureechanism (Liu et al., 1997b)he position of NAD in an isomorphous class 3 ALDH derivative and the emergence of Asn4/169 as a strictly conserved residue prompted us to consider the catalytic mechanism we present here.

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Agricultural Innovation in Asialso tpresence of ALDH1 as the 1-2% of human lens soluble protein. Furthermore, retina and real pigment epithelial (RPE) cells have been shown to play an important protective role fthe photosensitive cells of the eye against photo- and chemical toxicity.

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