Titlebook: Enzymology and Molecular Biology of Carbonyl Metabolism 5; Henry Weiner,Roger S. Holmes,Bendicht Wermuth Book 1995 The Editor(s) (if appli

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https://doi.org/10.1007/978-3-322-81341-1enotype experience alcohol-induced flushing that is secondary to high levels of circulating acetaldehyde (Harada ., 1981; Enomoto ., 1991b). This is commonly referred to as the Oriental alcohol flush reaction. Assays of liver extracts from individuals carrying a deficient allele have about half the

LIEN

https://doi.org/10.1057/9780230591387 inducer-receptor complex translocates into the nucleus, forms a heterodimer with the Ah receptor nuclear translocator (ARNT), and binds to one or more .romatic .ydrocarbon-.esponsive elements (AhREs) identified upstream of murine and rat ALDH3c genes (Asman et al., 1993; Vasiliou et al., 1994). In

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Enzymology and Molecular Biology of Carbonyl Metabolism 5

Inferior

micronized

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Preamble

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Class 3 Aldehyde Dehydrogenases in a number of tissues including the liver, colon and mammary tissue. All evidence to date indicates that both constitutive and inducible regulation of . gene occurs at the transcriptional level and involves use of both cis-acting elements and trans-acting factors.

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