Titlebook: Enzymology and Molecular Biology of Carbonyl Metabolism 3; Henry Weiner,Bendicht Wermuth,David W. Crabb Book 1991 The Editor(s) (if applic

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Role of Aldehyde Dehydrogenase (ALDH) in the Detoxication of Cyclophosphamide (CP) in Rat Embryostion has been quantified in rat liver homogenates, microsomes and whole parenchymal cells under various conditions of enhanced lipid peroxidation (Benedetti, et al., 1980; Esterbauer, et al., 1982; Poli, et al., 1985,1986).

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G. Riccioni,V. Sblendorio,N. D’Orazioner, 1979). Aldehyde dehydrogenase has been identified in virtually every organism and tissue examined. Distinct ALDHs have been identified in the mitochondrial, microsomal and cytosolic compartments of the cell (Tottmar et al., 1973; Greenfield and Pietruszko, 1977; Lindahl and Evces, 1984). Some f

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CLASP

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https://doi.org/10.1007/978-3-642-82101-1art of 35 residue tryptic peptide (Hempel, 1981; Hempel and Pietruszko, 1981; Hempel et al., 1982) by employing iodoacetamide. When the primary structures of the El and E2 isozymes were established (Hempel et al., 1984, 1985; Hsu et al., 1985), this cysteine was found to occupy position 302 in a 500

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Charles R. Filburn,Edward G. Lakattagive a complete picture of the mechanism of the aldehyde dehydrogenase catalyzed oxidation of propionaldehyde over an extended pH range. The enzyme catalyzed oxidation reaction at pH 7.0 and 7.6 is generally agreed to occur by the following ordered mechanism:.Scheme IAt least at low propionaldehyde

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Dean O. Smith,Julie L. Rosenheimerportant role in the toxic consequences of a deranged acetaldehyde metabolism in alcohol-related disorders (Agarwal and Goedde, 1989, 1990; Goedde and Agarwal, 1989). Two broadly defined groups of ALDHs have been recognized based upon their Michaelis constants (“l(fā)ow Km” and “high Km” isozymes). The m

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Warren Kline Bolton,Benjamin C. Sturgillal cells and the lens, by the absorption of UVR in the 290–320 nm wavelength range (UV-B) (Boettner and Wolters, 1962; Zigman, 1983). The mechanisms of corneal photoreception of UV-B light have not been determined, as yet, although studies examining the action spectra for the cornea in the induction

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Cognitive Changes in Older Adults,consumption. In humans, a single base pair mutation produces a catalytically inactive enzyme (Yoshida et al., 1984). Approximately 50% of Asians have this defective . allele; upon ingestion of ethanol, these individuals experience classic symptoms of acetaldehyde accumulation (Mizoi et al., 1979) wh