Titlebook: Enzyme-Prodrug Strategies for Cancer Therapy; Roger G. Melton,Richard J. Knox Book 1999 Springer Science+Business Media New York 1999 bioc

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Introduction,d by Ehrlich in the early years of this century (.). In practice, however, this goal has remained elusive as a range of obstacles have presented themselves and have proved very difficult to overcome. To date, there have been numerous attempts to improve the cytotoxicity of the antibody “missile” by

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Prodrugs in Cancer Chemotherapy, is the derivatization of this lead chemical to enhance its properties, for example, by reducing side effects and improving selectivity of action. In some instances the derivative has no intrinsic activity but is converted to the active drug, ., at the appropriate time or place. Such analogs are cal

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Early Clinical Studies with ADEPT, many ways a step into the unknown. It seemed possible, even likely, that new and unforeseen problems would emerge. To introduce a series of agents that would interact with each other . was in itself a cause for some apprehension. One of the main objectives of the first study was to identify new pro

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