Titlebook: Enzyme Kinetics in Drug Metabolism; Fundamentals and App Swati Nagar,Upendra A. Argikar,Donald Tweedie Book 2021Latest edition Springer Sci

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Increasing Agricultural Productivity, during chemotherapy treatment serves as a basis to discuss an example of sensitivity analysis. Second, an example of doxorubicin bioactivation is used for discussing points of consideration when constructing and analyzing network models of drug metabolism.

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Fundamentals of Enzyme Kinetics: Michaelis-Menten and Non-Michaelis–Type (Atypical) Enzyme KineticsDrug Metab Rev 36:231–242, 2004). Several cytochromes P450 (CYPs) have large active sites that enable binding of multiple molecules (Yano et al., J Biol Chem 279:38091–38094, 2004; Wester et al., J Biol Chem 279:35630–35637, 2004). Thus, atypical kinetics are not uncommon in in vitro drug metabolism studies.

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Numerical Methods for Modeling Enzyme Kineticsequations in the analysis of metabolism kinetics, reversible inhibition kinetics, and inactivation kinetics. The chapter describes the advantages of using numerical methods when Michaelis–Menten assumptions do not hold.

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Numerical Methods for Modeling Enzyme Kineticsed to solve differential equations. This chapter describes the use of numerical methods in solving differential equations and its applications in characterizing the complexities observed in enzyme kinetics. A discussion is included on the use of numerical methods to overcome limitations of explicit