Titlebook: Environmental Metal Pollutants, Reactive Oxygen Intermediaries and Genotoxicity; Molecular Approaches Maria E. Ariza,Gautam N. Bijur,Marsha

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The System of Community Correctionsal mechanisms that control cell proliferation.We now have an understanding of the molecular processes that are required for duplication of a cell and how disruption of these processes can result in cell death (apoptotic and necrotic). In the following sections, we will discuss the molecular processe

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Environmental Metal Pollutants: Sources and Determinants of Toxicity,n biological function (Table 1 and 2). The effects of metals, metalloids and compounds of these elements on health and behavior have been studied for hundreds of years. Large amounts of data have been accumulated concerning the toxic effects of metal compounds in biological systems. This has resulte

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Toxicological Profiles,kel), itai-itai disease (cadmium) and Minamata disease (methylmercury) are recognized clinical entities. There have been numerous studies performed, using different model systems, to determine the effects that metals and metalloids have on biological processes and to relate these effects to clinical

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Metals, Metalloids and Oxidative Stress,ng signal transduction, gene expression, cellular proliferation (cell cycle) and cell death (necrotic and apoptotic).The redox status of a cell reflects a delicate balance between two opposing factors: antioxidants that are produced by cells (glutathione and thioredoxin) or that are obtained from th

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Metals, Metalloids and Genetic Stability, compounds are carcinogenic. These studies stimulated investigations to determine the mechanism(s) by which metal and metalloid compounds are carcinogenic. As with any field of science, many mechanisms have been proposed. Over the years some have been disproven, and others have been modified, but we

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Effects of Environmental Metal and Metalloid Pollutants on Human Health,in some cases death. Blackfoot disease, hard metal lung disease, itai-itai and Minamata disease are well characterized diseases that are associated with metal exposure. Acute or chronic exposure to metal and metalloid compounds can result in damage to essentially all organ systems. Metal and metallo

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The System of Community Correctionss involved in cell cycle progression, the processes that regulate this progression and how disruption of these processes can lead to cell death (apoptosis) and/or to abnormal cell proliferation and genomic instability.

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