| 書目名稱 | Environmental Epigenomics in Health and Disease | | 副標(biāo)題 | Epigenetics and Dise | | 編輯 | Randy L Jirtle,Frederick L. Tyson | | 視頻video | http://file.papertrans.cn/313/312637/312637.mp4 | | 概述 | Provides evidence that environmental exposures during early development can alter the risk of developing medical conditions.Presents epigenetic processes that occur in human embryonic stem cells, as w | | 叢書名稱 | Epigenetics and Human Health | | 圖書封面 |  | | 描述 | There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome. | | 出版日期 | Book 2013 | | 關(guān)鍵詞 | Agouti mouse; CTCF dysfunction; chromatin switching; endocrine disruptors; environmental aromatic hydroc | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-23380-7 | | isbn_softcover | 978-3-642-42728-2 | | isbn_ebook | 978-3-642-23380-7Series ISSN 2191-2262 Series E-ISSN 2191-2270 | | issn_series | 2191-2262 | | copyright | Springer-Verlag Berlin Heidelberg 2013 |
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