Titlebook: Endothelin and Its Inhibitors; Timothy D. Warner Book 2001 Springer-Verlag Berlin Heidelberg 2001 Circulation.Endothelin.Glatte Muskulatur

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Jana Maeffert,Christiane Tennhardtlopmental roles of the ET system. Following these studies mutations of the ET-3 and ET-B receptor genes were identified in patients with human Hirschsprung’s disease. Thus, gene knockout studies paved the way to a new era of research not only on the ET system but also in the broader field of develop

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General Framework of Preconditionersned subtypes of ET. and ET. receptors have also been reported (Sudjarwo et al. 1994; Douglas et al. 1995). Various antagonists and agonists for ET receptors have been developed (Spellmeyer 1994; Warner 1994; Opgenorth 1995; Ohlstein et al. 1996; Wu-Wong et al. 1999; see Chaps 4, 9).

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Wie aus Gegens?tzen Optionen wurdenman and animal airway tissues established the presence of significant numbers of such receptors in several airway wall cell types in addition to airway and vascular smooth muscle (Henry et al. 1990; Goldie et al. 1995). Taken together, this information constituted a reasonable basis for speculating

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https://doi.org/10.1007/978-3-658-32100-0 several mechanisms that are important in fluid volume homeostasis and arterial pressure regulation. Furthermore, the role of ET-1 in several forms of renal failure suggest potential therapeutic targets for endothelin receptor antagonists. This chapter reviews the localization of the endothelin syst

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Endothelin Receptors,e likelihood that their activation is linked to the initiation, progression, and symptomology of various disease processes. These aspects of ET receptor biology have been excellently covered in earlier works (Huggins et al. 1993; Rubanyi and Polokoff 1994; Gray and Webb 1996), and detailed, up-to-da

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Lessons from Gene Deletion of Endothelin Systems,lopmental roles of the ET system. Following these studies mutations of the ET-3 and ET-B receptor genes were identified in patients with human Hirschsprung’s disease. Thus, gene knockout studies paved the way to a new era of research not only on the ET system but also in the broader field of develop

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