Titlebook: Endothelial Mechanisms of Vasomotor Control; With special Referen H. Drexler,A. M. Zeiher,H. Just Conference proceedings 1991 Dr. Dietrich

Glower

BABY

失望昨天

Role of EDRF and endothelin in coronary vasomotor controlugh ET is possibly the most potent constrictor of coronary arteries yet described, its role in physiological regulation of coronary vasomotor tone is less certain. Interactions between EDRF and ET in the coronary circulation are highlighted and a schema of regulation of release of endothelium-derived vasoactive factors is proposed.

FEMUR

PHON

(and organ perfusion) in health and disease. Physiology, pharmacology, and molecular biology have uncovered a wealth of information on structure and function of this heretofore largely neglected "organ". Clinical medicine is now called upon to define the clinical significance of these observa- tions

Anonymous

Introductiond with the maintenance of the liquidity of the blood. Only in 1976, when Moncada et al. discovered prostacyclin (17), and 1980, when Furchgott and Zawadzki (7) described the essential role of the intact endothelium for the vasodilatory action of acetylcholine, was the significance of this organ for

Ibd810

小官

草率女

Does EDRF/NO regulate its own release by increasing endothelial cyclic GMP?se cells contain considerable amounts of soluble guanylyl cyclase. The increase in cyclic GMP in these cells provided a sensitive bioassay for EDRF/NO activity. Bovine aortic endothelial cells released a material that markedly enhanced cyclic GMP in RFL-6 cells. The synthesis of this substance could

阻礙

Molecular mechanisms of nitrovasodilator bioactivationprodrugs or carriers of the active principle NO, responsible for endothelial controlled vasodilation. The rate of NO-formation strongly correlates with the activation of the soluble guanylate cyclase in vitro, resulting in a stimulation of cGMP synthesis. Nitrovasodilators thus are therapeutic subst