Titlebook: Endosomes; Ivan Dikic Book 2006 Springer-Verlag New York 2006 Lipid.membrane.protein.proteins.receptor.replication.signal transduction

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Christina Hofer-Dückelmann,Günter Fellhoferd their ability to exploit, in its finest details, the membrane-trafficking systems of their hosts. In this chapter, based on selected examples we will review how toxins use the host endosomal system to reach their targets.

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Lipid Membrane Domains in Endosomes,le, the intraluminal and limiting membranes of multivesicular compartments. Evidence also shows that endosomes contain different lipid territories, and that such territories overlap with morphologically visible domains. Here, we will discuss recent advances in our understanding of the role of these

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Enrage

Synaptic Endosomes,ion of pre- and post-synaptic membrane proteins. Recent data indicate that they play a role in maintaining the pool of small synaptic vesicles and are involved in recycling of dense-core vesicle membrane during neurotransmitter release.

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Clathrin Adaptor Proteins in Cargo Endocytosis,eval typically involves inward budding of small bilayer-encapsulated vesicles that shuttle protein and lipid from the surface to internal endosomal elements. Clathrin-mediated endocytosis is a dominant pathway for internalization in many cell types, and a range of dedicated signals are used to ensur

冷峻

Protein Sorting in Endosomes,hunted retrogradely to the biosynthetic pathway. The distinct fates of different endosomal cargo molecules point to the existence of sorting machineries able to distinguish between cargoes. In this review we will highlight recent studies that are beginning to elucidate the endosomal sorting machiner

Contracture

Signaling from Internalized Receptors,ays been viewed primarily as a mechanism to negatively regulate receptor activation, but recent evidence suggests that internalization may result in the formation of specialized signaling platforms on intracellular vesicles. Thus, the investigation of the molecular composition of the various vesicul

Intercept

Endocytosis of Receptor Tyrosine Kinases,ty, as well as in pathogenesis, including cancer. The amplitude and kinetics of growth factor signaling are determined mainly by a highly regulated endocytic process, which sorts activated receptors to degradation in lysosomes. Molecular mechanisms underlying receptor down-regulation are being unrav