Titlebook: Endorphins and Opiate Antagonists in Psychiatric Research; Clinical Implication Nandkumar S. Shah (Chief of Research Services, Res Book 198

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,Allgemeines – Общая информация, various psychiatric disorders. It is but natural to link a newly discovered naturally occurring substance to the disease states, particularly when the substance seems to have related physiological functions. Hence, abnormalities in its disposition can obviously be implicated in these diseases. In r

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https://doi.org/10.1007/978-3-662-62044-1of phenylketonuric patients (Folling, 1934), This approach has proved to be extremely productive in identifying biochemical markers, predicting enzymatic lesions, and finally pinpointing the genetic basis of a large number of metabolic diseases inherited in Mendelian fashion (Stanbury .., 1978). Alt

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chemoprevention

,β-Endorphin and Central Nervous System,of the biologically most active opioids is β-endorphin, which, in the CNS, apparently is localized intraneuronally (Bloom ..,1978; Watson ..,1978) and has been implicated as a putative neurotransmitter, neuromodulator or neurohormone (Bloom ..,1976; Gispen ..,1977; Nicoll ..,1977; Barchas ..,1978; Donovan, 1978; Kastin .., 1979; Riley .., 1980).

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Endorphins in Psychiatric Research and Treatment, release-inhibiting factors, produced in the hypothalamus and transported to the pituitary gland via the bloodstream (portal vascular system between hypothalamus and pituitary gland). Neurohypophyseal hormones produced in the hypothalamus are transported via neurons to the posterior pituitary lobe where they are stored.

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Ryan C. Maness,Brandon Valerianots of a number of recent studies have suggested a close relationship between enkephalinergic and dopaminergic neurons, and also a possible role of the endogenous opiate peptides in the pathogenesis of some mental disorders (Jacquet and Marks, 1976; Frederickson, 1977; Verebey .., 1978; Watson .., 1979; Bowers, 1980).

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