Titlebook: Endocrinology of the Testis and Male Reproduction; Manuela Simoni,Ilpo T. Huhtaniemi Reference work 2017 Springer International Publishing

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Gonadotropinsroduction. LH and FSH are synthesized in the gonadotropes of the anterior pituitary gland, while CG is synthesized by the placental syncytiotrophoblasts. Gonadotropins, together with thyroid-stimulating hormone (TSH) synthesized by the thyrotropes of the adenohypophysis, belong to the glycoprotein h

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Sex Determinationiation of the gonad into a testis or ovary. The gonad develops as an undifferentiated primordium that is initially indistinguishable between XX (female) and XY (male) embryos; the gonad is a uniquely bipotential organ in its ability to give rise to a testis or ovary. Prior to sex determination, the

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Male Sexual Differentiationdges contain three main types of bipotential precursor cells: supporting cells, which in the developing testis differentiate into Sertoli cells, steroidogenic cells giving rise to Leydig cells, and primordial germ cells developing into sperm. Each of these cell types play a critical role in the deve

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Endocrinology of the Fetal Testisollowing sex determination at around weeks 5–6, the somatic cells of the testis begin to differentiate into hormone-producing Sertoli and Leydig cells. The latter cells share similar origins to the steroidogenic cells of the adrenal cortex and fetal zones which at this stage of human development are

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Functional Anatomy and Histology of the Testis epididymis for further maturation and storage..Especially the endocrine function requires a specific anatomical and histological structure of the testis, i.e., a special “l(fā)ocation” of the testis outside the body in the scrotum, a sophisticated blood supply, and the development of lobes within the t

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Testicular Steroidogenesisrom cholesterol occurs via a series of enzymatic reactions. Testosterone may be further metabolized into a more potent androgen, dihydrotestosterone. In recent years an alternate pathway of dihydrotestosterone biosynthesis without using testosterone as a precursor has emerged. Majority of classicall