Titlebook: Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles; Philippe Chanson,Jacques Epelbaum,Yves Christen Book 2004 Springer-

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IGF-1 and Insulin Signaling in the Control of Longevity,ife. Increased life expectancy appears to be due to delayed aging in at least three of these four mutants. Ames dwarf (Prop1.) and Snell dwarf (Pitl .) mice have primary deficiency of growth hormone (GH), prolactin and thyrotropin, little (GHRHR.) mice have GH releasing hormone resistance, and GHR-K

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IGF-1 Gene Polymorphisms and Disease in the Elderly,cade, while a further two-fold decrease occurs between the third and eighth decades. Besides growth hormone (GH), age, nutrition and a number of other factors, individual circulating IGF-I concentrations are also influenced by a number of genetic factors. Twin studies have shown that at least 38% of

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Polymorphisms and Male Ageing,al and pathological functions of the human body. Besides clear disease-causing mutations, subtle polymorphisms are likely to determine a great deal of the interindividual variability of morbidity in general and, specifically, of the phenomenon of ageing. With respect to the gender-specific features

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Age-related Changes in the Regulation of the Hypothalamic-Pituitary Adrenal Axis: The Role of Persont of a stressor, and as a consequence a cascade of hormones is released that serve different functions throughout the human organism, generally aimed at providing the necessary metabolic and immunomodulatory adjustments in response to a physiological or psychological stressor..Basal secretion of th

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Aging Myelin and Cognitive Decline: a Role for Steroids,umber of vital neuronal and glial functions throughout the brain and in peripheral nerves. For example, progesterone exerts neuroprotective effects and plays an important role in myelination. This steroid, which is produced by the ovaries and adrenal glands and then reaches the nervous tissues via t