Titlebook: Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders; Elisabeth J. Van Bockstaele Book 2013 Springer Science

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Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders978-1-4614-7940-6

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Gender Disparity of Depression: The Role of Endocannabinoids and Noradrenergic Function,response being a major area of interaction. Norepinephrine acts as a “gatekeeper” to the body’s stress response, mobilizing the HPA axis to react to stressors. The endocannabinoid system is also a “gatekeeper” to this response, preventing maladaptive HPA hyperactivation and potentially protecting th

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Cannabinoids, Monoamines, COMT and Schizophrenia: Pathobiological Mechanisms in Psychosis,as shown showing that variation in the genes implicated in dopamine neurotransmission (COMT, AKT1, D2R) moderates the psychotomimetic effects of cannabis exposure. Further studies are required to clarify the molecular underpinnings of dopamine system involvement in cannabis-induced psychosis.

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Structuring the Knowledge Management System, Allosteric modulation of cannabinoid receptors may usher in new classes of medicinal compounds capable of enhancing signals generated by endocannabinoids. Natural polymorphisms and alternative splice variants may also contribute to the pharmacological diversity of the cannabinoid receptors. Thus, e

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