Titlebook: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2; Part A Kenneth V. Honn,Santosh Nigam,Lawrence J. Ma

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The Effects of Group II Phospholipase A, on ,-Induced Metastasisy and metastasis in animal model systems (1–3). Therefore, the specific .-induced alterations which facilitate primary tumor growth and metastasis are clearly of interest. The introduction of a . gene product (p21) in eucaryotic cells causes transformation .. This transformation has also been associ

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High Molecular Weight Phospholipase A2: Its Occurrence and Quantification in Human Colon Cancer and tood. Lipid peroxidation, phospholipase A. activity and myeloperoxidase activity were increased in colorectal cancers compared with macroscopically normal tissues (Otamiri et al. 1989). Varying amounts of total arachidonic acid in the phospholipids of colorectal tumors compared to normal associated

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-Type Lipoxygenase and Cyclooxygenase Reaction Box Models Characterizing the Stereochemistry of the which contains a non-heme iron. The common characteristics of the reaction catalyzed by .-type lipoxygenases (LOX) include:. i) substrates with a .-1,4-pentadiene structure, preferably in afree fatty acid, ii) a three step reaction mechanism consisting of hydrogen abstraction at C(3) of the pentadi