Titlebook: Eicosanoids; From Biotechnology t Gian Carlo Folco,Bengt Samuelsson,G. P. Velo Book 1996 Springer Science+Business Media New York 1996 Mamm

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Overview: 978-1-4899-0202-3978-1-4899-0200-9

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Artificial Intelligence and Slingshots,idase activities (DeWitt, 1991). PGH2 is further metabolized by other enzymes to various prostanoids (PGs, prostacyclin and thromboxane A2). Two isozymes of PGHS are known, referred to as PGHS-1 and PGHS-2 (Smith, 1992). PGHS-1 is a constitutive enzyme present in almost all cell types (Simmons et al

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https://doi.org/10.1007/978-1-4842-5308-3ances of intracellular communication and cellular activation. Discoveries of their biological activities and roles in normal physiology and pathophysiology are legion. An important question to consider with such biologically active compounds is how activity is terminated. For eicosanoids, metabolism

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https://doi.org/10.1057/9780230594043types in order to determine the structure of end-products generated by a given cell. This approach has delineated specific enzymic patterns by certain cells in the blood and in the vasculature (Table I). Platelets produce mainly 12-hydroxy-eicosatetraenoic acid, 12-hydroxy-heptadecatrienoic acid and

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