Titlebook: EJB Reviews 1994; P. Christen,E. Hofmann Book 1995 Federation of European Biochemical Societies 1995 Biochemie.Biochemistry.Biophysics.Bio

NAIVE

河潭

Rack-induced bonding in blue-copper proteins,ling in the EPR spectrum, are reviewed. The concept of rack-induced bonding is summarized. The tertiary structure of the protein creates a preformed chelating site with very little flexibility, the geometry of which is in conflict with that preferred by Cu.. The structure of the metal site in azurin

peak-flow

Structure and modifications of the junior chaperone ,-crystallin,ts as an aggregate of about 800 kDa, but its composition is simple. Only two closely related subunits termed .A- and .B-crystallin, with molecular masses of approximately 20 kDa, form the building blocks of the aggregate.

門閂

使厭惡

Signal-transduction therapy,as cancers, atherosclerosis and psoriasis and inflammatory conditions such as sepsis, rheumatoid arthritis and tissue rejection. These findings refocused the research of the medical community to seek new modalities for disease management which essentially consist of designing drugs which intercept c

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乞討

Gene-targeting approaches in the study of cellular processes involved in growth or differentiation,and thereby selectively generate mutant mice. Genetically manipulated mutant mice have contributed enormously to our understanding of the molecular functions of isolated genes and the mechanisms of cell growth and differentiation, as well as increasing our understanding of diseases such as cancer. H

Stagger

Eviction

X-ray crystal structures of cytosolic glutathione ,-transferases,g at the two adjacent subsites of the active site. Considerable progress has been made in understanding the mechanism whereby the thiol group of glutathione is destabilized (lowering its p..) at the active site, a rate-enhancement strategy shared by the soluble glutathione .-trans- ferases.

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