Titlebook: Dynamics of Cholinergic Function; Israel Hanin Book 1986 Plenum Press, New York 1986 USA.development.dynamics.flow.kinetics.mechanism.mech

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Cortical Cholinergic Hypofunction and Behavioral Impairment Produced by Basal Forebrain Lesions in ts that cortical cholinergic dysfunction may underlie certain learning and memory deficits in AD. The present communication is part of an ongoing effort aimed at investigating the role of the MNBF-cortical pathway in memory and developing a useful animal model of AD (8, 18).

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Interactions of Calcium Homeostasis, Acetylcholine Metabolism, Behavior and 3,4-Diaminopyridine duri 62). The molecular mechanisms that lead to the decline in brain function with aging and their relation to the biochemical basis of the debilitating deficits of Alzheimer’s disease are unknown. The similarities between aging and Alzheimer’s disease are detailed elsewhere (18).

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Identification of Putative M1 Muscarinic Receptors Using [3H]Pirenzepine: Characterization of Bindinlation to the growing body of evidence which supports the M./M. hypothesis. Emphasis is placed upon our studies of human stellate ganglia. Several relevant reviews have recently appeared in the literature (3, 22, 23, 29).

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Relationships between Choline Acetyltransferase and Muscarinic Binding in Aging Rodent Brain and in A/J mice, we have observed age-dependent increases in ChAT (26); whereas, other studies have revealed no changes or decreases in the brains of C57BL/6J mice (23, 25), other mouse strains (24), and rats (2, 23, 25).

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